Smart manufacturing is the trend of modern industrial technology development. In order to understand the safety management policies and regulations of various countries for smart manufacturing machinery and equipment, and to share the implementation experience with the competent government departments of friendly countries to assist our industry in pre-planning safety measures. To enhance occupational safety environment, workers safety and facilitate global economic development, Occupational Safety and Health Administration (OSHA) and Precision Machinery Research and Development Center (PMC) co-host “International Seminar of Safety Management of Machinery and Equipment for Smart Manufacturing” that took place on October 5, 2021 at the conference room 301 of GIS Taichung Xinwuri Convention Center. This year the seminar invited experts in the field of safety management of machinery and equipment for smart manufacturing from Singapore, Japan, EU and Taiwan industries with participation of local industries total 1,215 participants (the online participants were 1,175, and the physical participants were 40) to exchange technical discussion and practices in regard to safety management of machinery and equipment for smart manufacturing. This seminar prompted opportunities for global communication and possible cooperation while enhancing safety verification capabilities for Taiwan local industries and certification bodies.